Welcome to the NORCHI homepage.

This page contains information about NORCHI together with a link to the NORCHI online database.

RMCH Royal Manchester Children's Hospital.
AH Alder Hey Children's Hospital.

The Northern Congenital Hyperinsulinism Service (NORCHI) is a specialist centre in the north of the UK, which has been commissioned by the National Commissioning Group (NCG) for the management of children with the rare and difficult condition of Congenital Hyperinsulinism (CHI). NORCHI comprises of two centres, the Royal Manchester Children's Hospital (RMCH) in Manchester and Alder Hey Children's Hospital (AHCH) in Liverpool. Since its inception in 2006, NORCHI has successfully managed children not only from Greater Manchester and Liverpool, but also from other areas such as North Wales, Stoke on Trent and Nottingham.

NORCHI has a team of consultant paediatric endocrinologists, consultant paediatric surgeons, a specialist nurse, a clinical research fellow and secretarial support who work across both sites along with radiologists, dieticians, biochemists, psychologists and administrative staff to provide the infrastructure for expert multi-disciplinary care. This includes early and accurate diagnosis of CHI, stabilisation of hypoglycaemia, surgical central line insertion, drug therapy, genetic analysis and providing parental support. An important part of the investigation of CHI is the determination of focal CHI, which is amenable to curative focal pancreatectomy, thereby reducing the need for long term medication and/or diabetes complicating total pancreatectomy. NORCHI has collaborative links with Berlin, where we send children for PET-CT scans to help diagnose and localise focal CHI before surgery. We liaise with the other CHI centre in the country, Great Ormond Street Hospital in London, to ensure uniformity of practice and to maintain the highest standard of care for our patients.

In NORCHI, we understand the need to sustain a strong research interest to improve the quality of clinical management. Data from patients are entered into a robust database to aid clinical research into CHI. Older children with CHI are assessed by psychometry to understand better the effects of hypoglycaemia in early life. The Pathophysiology Studies of CHI (CHIPS) basic science research is likely to enhance our understanding of CHI at a cellular level. Our collaboration with Exeter on the genetic aspects of CHI is expected to have direct clinical relevance to the management of children with CHI.

We hope that you will find information on this website interesting and stimulating.